- Nachiket S. Dighe
- Sanjay B. Bhawar
- Santosh B. Dighe
- Mayur S. Bhosale
- Vishal B. Tambe
- Vinayak M. Gaware
- Mangesh B. Hole
- Sapana M. Nagare
- Deepak S. Musmade
- Manisha S. Kedar
- Smita K. Parjane
- Priyanka P. Gadhave
- Manjusha S. Sanap
- Abhijeet N. Merekar
- Deepak K. Thakur
- Pratik V. Patel
- H. V. Shinde
- Sunil A. Nirmal
- Prerana A. Chavan
- Nilesh Jadhao
- Vipul V. Dhasade
- Shruti G. Dake
- Madhuri U. Shelar
- Vinayak Gaware
- V. D. Pujar
- S. N. Hiremath
- R. B. Laware
- S. G. Jadhav
- Medha A. Khade
- Anand A. Bukitagar
- Snehlata K. Tambe
- S. V. Hiremath
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Pattan, Shashikant R.
- Rocky Mountain Fever: A Review
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P- Loni Bk. Taluka-Rahata, Dist-Ahmednagar 413736, (MS), IN
2 Department Of Medicinal Chemistry, Pravara Rural College Of Pharmacy, Pravaranagar, M.S., IN
3 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
4 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
5 Department Of Medicinal Chemistry, Pravara Rural College Of Pharmacy,Pravaranagar, M.S., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 104-110Abstract
Rocky Mountain spotted fever (RMSF) is a disease caused by the bacterium Rickettsia rickettsii which is spread to humans by ticks. Symptoms include the sudden onset of fever, headache and muscle pain followed by the development of a rash. In the laboratory, rickettsiae cannot be cultivated on agar plates or in broth, but only in viable eukaryotic host cells. Rocky Mountain spotted fever and Mediterranean spotted fever are rickettsial infections primarily of endothelial cells that normally have a potent anticoagulant function. As a result of endothelial cell infection and injury, the hemostatic system is perturbed and shows changes that vary widely from a minor reduction in the platelet count to severe coagulopathies, such as deep venous thrombosis and disseminated intravascular coagulation. Animals probably become infected by aerosol and by the bite of any of the 40 species of ticks that carry the organisms. From the portal of entry in the skin, rickettsiae spread via the bloodstream to infect the endothelium and sometimes the vascular smooth muscle cells, brain, lungs, heart, kidneys, liver, gastrointestinal tract and other organs. Rickettsia species enter their target cells, multiply by binary fission in the cytosol and damage heavily parasitized cells directly. The target cells are macrophages in the lungs, liver, bone marrow, spleen, heart valves and other organs. Clinico-epidemiologic diagnosis is ultimately a matter of suspicion. Empirical treatment and later laboratory confirmation gives specific diagnosis. Some laboratories are able to identify rickettsiae by immunohistology in skin biopsies as a timely, acute diagnostic procedure, but to establish the diagnosis; physicians usually rely on serologic demonstration of the development of antibodies to rickettsial antigens in serum collected after the patient has recovered. Currently, assays that demonstrate antibodies to rickettsial antigens themselves are preferable to the nonspecific, insensitive Weil-Felix test that is based on the crossreactive antigens of OX-19 and OX-2 strains. Tetracycline, Doxycycline and chloramphenicol are the drugs of choice for treatment. Control of the tick population on the property, keeping pets tick-free are some measures to control the disease.Keywords
Black Measles, Chloramphenicol, Rickettsia, Tetracycline.References
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- Tools for Synthesis of Natural Products:An Overview
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN
Source
Research Journal of Science and Technology, Vol 1, No 2 (2009), Pagination: 49-54Abstract
The present review article on tools for synthesis of natural products is to significantly facilitate organic synthesis of natural products which are of significant biological importance by the implementation of new concepts for catalysis. We focus on the recent development in natural product synthesis with the help of newer methods of organic synthesis.Keywords
Natural Products, Methods of Synthesis, Combinatorial Chemistry.- Recent Synthesis of Marine Natural Products with Anticancer Activity:An Overview
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
Source
Research Journal of Science and Technology, Vol 1, No 2 (2009), Pagination: 63-70Abstract
Many natural products from marine sources are endowed with promising anti cancer activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of anti cancer marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted.Keywords
Marine, Anti Cancer Activity, Synthesis of Dictyostatin.- Umpolung Chemistry:An Overview
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P- Loni Bk. Taluka -Rahata, Dist-Ahmednagar 413736, IN
Source
Research Journal of Science and Technology, Vol 1, No 1 (2009), Pagination: 8-12Abstract
The present review article on Umpolung chemistry is to significantly facilitate organic synthesis by the implementation of new concepts for catalysis. We focus on the recent development of N- heterocyclic carbenes mediated organic reaction and its implementation to the synthesis of heterocycles of biological importance.Keywords
Umpolung, N-Heterocyclic Carbenes, Organomettalic Catalyst.- An Overview of Cassia fistula:Chemistry and Pharmacological Profile
Authors
1 Pravara Rural College of Pharmacy, Loni, M.S., IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/PLoni Bk. Taluka -Rahata, Dist- Ahmednagar 413736, (MS), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 143-145Abstract
Cassia fistula Linn (Leguminosae) is a shrub, extensively used in traditional medicine in tropical and warm subtropical countries. C. Fistula commonly found in waste grounds and secondary forest. The chemical constituents reported from this plant belong to different classes such as glycosides, flavonoides, steroids, mucilage and sugars. C. Fistula has number of medicinal uses, many of which have been verified by scientific methods. This review article summarizes the chemistry and pharmacological profile of C. Fistula.
Keywords
Cassia fistula, Phytochemistry, Pharmacological Activities.- A Review on Phytochemical and Pharmacological Profile of Cassia tora Linn
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/PLoni Bk.Taluka -Rahata,Dist- Ahmednagar 413736, (MS), IN
2 Pravara Rural College of Pharmacy, Pravaranagar, M.S, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 173-176Abstract
Cassia tora Linn (Leguminosae) is a shrub, extensively used in traditional medicine in tropical and warm substropical countries. C. tora commonly found in waste grounds and secondary forest. The chemical constituents reported from this plant belong to different classes such as glycosides, tannins, flavonoides, steroids, resins, mucilage and sugars. C. tora has number of medicinal uses, many of which have been verified by scientific methods. This review article summarizes the chemistry and pharmacological profile of C. tora.
Keywords
Cassia tora, Phytochemistry, Pharmacological Activity, Anthraquinone Glycoside.- Synthesis and Anti-Inflammatory Activity of 2-Amino Substituted Benzothiazoles
Authors
1 Pravara Rural College of Pharmacy, Loni-413736, M.S., IN
2 KLE’S College of Pharmacy, Belgaum, IN
3 College of Pharmacy, Chincholi, Nashik, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 113-115Abstract
A new series of 2-amino substituted benzothiazoles and their derivatives were prepared by multiple steps. The structures of the synthesized compounds were confirmed by Melting point, TLC, IR, and H1NMR. The compounds were screened for their anti-inflammatory activity, all the compounds shown promising anti-inflammatory activity.Keywords
2-Amino-Substituted-Benzothiazoles, Anti-Inflammatory, CHN Analysis.- Synthesis and Antidiabetic Activity of Some New Benzopyrone Derivatives
Authors
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni Bk-413736, Tal Rahata, Dist Ahmednagar, (MS), IN
2 College of Pharmacy, Chincholi, Nashik, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 126-128Abstract
A new series of benzopyrone derivatives were synthesized and the structure of these compounds was established on the basis of spectral data. The title compounds were evaluated for antidiabetic activity. Some of these compounds have shown excellent antidiabetic activity.Keywords
Benzopyrone, Antidiabetic, CHN Analysis.- Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity
Authors
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
2 Department of Pharmacology, JNMC, Belgaum, Karnataka, IN